Nazi-occupied Amsterdam, Otto Frank and his family have decided to go into hiding, because of the increasing persecutions against Jews. The businessman Victor Kugler and his assistant Miep Geis prepare a hiding place in the rooms above their place of business, and arrange for the Franks and another family, the van Pels, to stay there. Later on, they are joined by the dentist Fitz Pfeffer. Together, they try to avoid detection while hoping for Amsterdam to be liberated by the Allies, but even meeting basic needs can become a challenge, and even minor incidents could present a grave risk.