Wake Forest has won a total of eight national championships in four different sports; four of these championships have come in the past six years. Wake Forest is sometimes referred to as being a part of "Tobacco Road" or the "The Big Four," terms that refer to the four North Carolina schools that compete heatedly against each other within the ACC; these include Duke, North Carolina, and North Carolina State, as well as Wake Forest.

The Demon Deacons participate in the NCAA's Division I (in the Bowl Subdivision for football) and in the Atlantic Coast Conference.

The Athletics Director is Ron Wellman.

Wake Forest is generally regarded as a competitive program in men's basketball, frequently qualifying for the NCAA Men's Division I Basketball Championship (20 times in the school's history). The men's basketball team has made 16 straight postseason appearances (through their NIT appearance in 2006), the longest such streak in the ACC. They reached the Final Four once, in 1962. The school's famous basketball alumni include Billy Packer, a guard on the 1962 Final Four team who became far more famous as a basketball broadcaster; "Muggsy" Bogues, the shortest player ever to play in the NBA; Randolph Childress, for his MVP performance in the 1995 ACC Tournament; Dallas Mavericks star Josh Howard; 2006 NBA Rookie of the Year Award winner and New Orleans Hornets star Chris Paul; and two-time league MVP and three-time NBA Finals MVP San Antonio Spurs forward Tim Duncan. Lawrence Joel Veterans Memorial Coliseum is the home venue for the Demon Deacons basketball team. Skip Prosser, Wake Forest University's men's basketball coach since 2001, died in Winston-Salem on July 26, 2007. One of Prosser's assistant coaches, Dino Gaudio, was named to replace him.

Date	Opponent / Event	Location	Time / Result
11/05/09	vs. IUP (Exhibition)	Winston-Salem, N.C.	W, 88-57
11/13/09	vs. Oral Roberts	Winston-Salem, N.C.	W, 76-56
11/15/09	at East Carolina	Greensboro, N.C. (Greensboro Coliseum)	W, 89-58
11/18/09	vs. High Point	Winston-Salem, N.C.	W, 83-60
11/24/09	vs. Winston-Salem State	Winston-Salem, N.C.	W, 76-52
11/28/09	vs. William & Mary	Winston-Salem, N.C.	L, 78-68
12/01/09	at Purdue	West Lafayette, Ind.	L, 69-58
12/05/09	at Gonzaga	Spokane, Wash.	W, 77-75
12/13/09	vs. Elon	Winston-Salem, N.C.	W, 90-50
12/16/09	at UNC Wilmington	Wilmington, N.C.	W, 80-69
12/20/09	vs. NC State	Winston-Salem, N.C.	W, 67-59
12/28/09	at UNC Greensboro	Greensboro, N.C. (Greensboro Coliseum)	W, 75-60
12/31/09	vs. Richmond	Winston-Salem, N.C.	W, 74-68 (OT)
01/03/10	vs. Xavier	Winston-Salem, N.C.	W, 96-92 (2OT)
01/09/10	at Miami	Coral Gables, Fla.	L, 67-66
01/12/10	vs. Maryland	Winston-Salem, N.C.	W, 85-83 (OT)
01/17/10	at Duke	Durham, N.C.	L, 90-70
01/20/10	at North Carolina	Chapel Hill, N.C.	W, 82-69
01/23/10	vs. Virginia	Winston-Salem, N.C.	W, 69-57
01/28/10	at Georgia Tech	Atlanta, Ga.	L, 79-58
02/02/10	vs. Miami	Winston-Salem, N.C.	W, 62-53
02/06/10	at Virginia	Charlottesville, Va.	W, 64-61 (OT)
02/09/10	vs. Boston College	Winston-Salem, N.C.	W, 92-85
02/13/10	vs. Georgia Tech	Winston-Salem, N.C.	W, 75-64
02/16/10	at Virginia Tech	Blacksburg, Va.	L, 87-83
02/20/10	at NC State	Raleigh, N.C.	L, 68-54
02/27/10	vs. North Carolina	Winston-Salem, N.C.	L, 77-68
03/03/10	at Florida State	Tallahassee, Fla.	L, 51-47
03/07/10	vs. Clemson	Winston-Salem, N.C.	W, 70-65